CD8+T lymphocytes infiltrating breast cancer
نویسندگان
چکیده
منابع مشابه
Tumor-infiltrating lymphocytes in breast cancer
We have prospectively validated in an independent clinical cohort the finding that elevated amounts of tumor-infiltrating lymphocytes in breast carcinoma tissues predict the response of patients to neoadjuvant chemotherapy. These results suggest that a robust tumor infiltration by T and B cells is a promising biomarker to define patients who might benefit from neoadjuvant chemotherapy.
متن کاملCD8+ T lymphocytes infiltrating breast cancer
Lymphocytic infiltration is often seen in breast cancer and has been suggested as a marker of host anti-tumor response but its importance in prognosis remains controversial. Our recent study demonstrated an association between tumor-infiltrating CD8(+) T lymphocytes in invasive breast cancer and better prognosis.
متن کاملRelevance of tumor-infiltrating lymphocytes in breast cancer
While breast cancer has not been considered a cancer amenable to immunotherapeutic approaches, recent studies have demonstrated evidence of significant immune cell infiltration via tumor-infiltrating lymphocytes in a subset of patient tumors. In this review we present the current evidence highlighting the clinical relevance and utility of tumor-infiltrating lymphocytes in breast cancer. Retrosp...
متن کاملCharacterization and quantification of tumor infiltrating lymphocytes in breast cancer
Results A positive correlation between CD3 and CD8 expression (rs=0.614, n=24, P 0.001) and CD3 and CD45RO expression (rs=0.621, n=24, P 0.001) were noted in the center of the tumor (CT).CD3 median percentage in CT was higher in grade 2 and grade 3 breast carcinoma compared to grade 1 (P 0.023). CD3 in the center of the tumor and CD8 in the invasive margins (IM) were significantly higher in ER/...
متن کاملTumor-infiltrating lymphocytes, breast cancer subtypes and therapeutic efficacy
By analyzing over 2000 samples from a randomized clinical trial, we have recently associated high levels of tumor-infiltrating lymphocytes with an excellent prognosis among triple negative breast cancer patients as well with improved clinical responses to immunogenic chemotherapy among patients bearing HER2 over-expression. These findings suggest that immunomodulation could represent a new appr...
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ژورنال
عنوان ژورنال: OncoImmunology
سال: 2012
ISSN: 2162-402X
DOI: 10.4161/onci.18614